BSE/TSE Free

Australia’s Animal Health Status

Australia’s BSE-free status has been internationally recognized with the European Scientific Steering Committee’s highest category (Category One) of BSE-freedom.

Australia and New Zealand are two of only a few countries with an EU Category One listing sharing this BSE disease-free status with others such as Singapore, Iceland, Namibia and Vanuatu. Australia is also free of List A diseases as defined by the World Organization for Animal Health (OIE).

It is also free of the wasting diseases scrapie in sheep and chronic wasting disease amongst indigenous wild animal herds. The US recognizes only two countries in the world as free of scrapie – Australia and New Zealand.

Leptoshira Growth

BOVOLEP – Premium Grade

BovoLep BSA product is a highly purified BSA product which has been fortified with a specially formulated ‘cocktail’ of non-animal, synthetic lipids for the enhanced growth of fastidious organisms such as Leptospira. This product has been shown to significantly enhance the growth of cultures through the availability of essential nutrients which are absent in highly purified BSA fractions.

BovoLep BSA has also been shown to significantly improve the performance of mammalian cells when used as an adjunct in culture media.

• Hygienic plasma collection from USDA/EU approved abattoirs
• Plasma collection uses a closed loop collection system
• Only plasma of 100% Australian origin is used
• Australia has the highest global animal disease free status
• BSA is manufactured under strict GMP conditions
• Heat shock process incorporating a viral inactivating agent
• Proprietary technology supports a cost competitive product
• Bulk lots reserved for specific customers upon negotiation
• Variant BSA products can be manufactured upon request

Aprotinin Summary

Living cells contain the biochemical systems for their own destruction, namely digestive hydrolytic enzymes. These include nucleases, polysaccharidases, phosphatases and proteinases. In mammalian cells these enzymes are stored in lysosomes. They are released and directed under controlled conditions to specific molecules to catalyse their hydrolytic degradation.

In cell cultivation and protein extractions from cell culture the balance of these cellular systems are usually disrupted leading to uncontrolled enzyme release. This event may cause a rapid degradation of the desired product.

The use of a proteinase inhibitors added to the cell culture or extraction purification batches may stop the loss of product by proteolysis.

Aprotinin is a natural inhibitor of trypsin, chymotrypsin and plasmin. Many times dangerous substances such as dfp or pmsf are not warranted and aprotinin may be used instead.

Aprotinin is the generic name for the basic trypsin inhibitor from bovine organs. Desert biological’s aprotinin comes from new zealand bovine beef lung.

DIAGNOSTIC PROCEDURES
Aprotinin exhibits a protective effect against proteolytic reactions during immunodiffusion, radioimmunoassay or enzyme linked immune assay procedures.

BLOOD AND ORGAN PRESERVATION
Aprotinin is used to preserve platelet number and function for transfusion. In animal experimentation aprotinin has been used to preserve organs for transplantation.

AFFINITY CHROMATOGRAPHY
Protinases sensitive to aprotinin can easily be purified by affinity chromatography with immobilized aprotinin.

BIOLOGICAL MATERIALS
Aprotinin may be used to inhibit proteolytic reactions during collection, preparation and storage of biological fluids and tissue extracts as well as purification of polypeptides and proteins. In cell culture media aprotinin inhibits degradation of proteohormones. It can also extend the life span of certain cells in culture.

NEW ZEALAND ORIGIN
Desert biologicals aprotinin is manufactured in new zealand. The low incidence of bovine related disease in new zealand has created a strong international demand for animal derived biologicals. The meat and glands used are generally free from hormonal, chemical, antibiotic and heavy metal residues, thanks to new zealand’s advanced animal husbandry practices.